About

05/01/2014

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I am a final-year PhD student co-supervised by Dr. Matt Berriman and Prof. Dominic Kwiatkowski. My PhD project involves analysing the DNA sequences of human malaria parasites to elucidate their evolutionary history and to better understand the genetic basis of antimalarial drug resistance. I am due to complete my PhD by October 2018.

Brief Research Summary

As intensive control efforts are successfully reducing malaria prevalence in many countries, the focus is now shifting towards more targeted interventions that rely on effective surveillance mechanisms. Using the information encoded in the genome sequences of malaria parasites to monitor changes in transmission dynamics and drug resistance occurrence presents a cost-effective way of surveillance. My PhD project consists of multiple strands of research, including assembling genome sequences of neglected malaria parasite species to enable their study and surveillance, connecting genetic data to drug resistance phenotype data to better understand the genetic basis of antimalarial drug resistance, as well as developing the mathematical models needed to convert these genetic findings from multiple genome sequences into actionable public health measures.

Biography

I completed my BSc (Hons.) in Biology and English with First class honours at the University of Keele, UK, in 2012 and was awarded the Society of Biology Top Student award. I subsequently completed an MSc in Quantitative Biology at Imperial College London, UK, in 2013, where I was awarded the William Harvey Prize and where I analysed patterns of genetic differentiation in wild mosquito populations under the supervision of Prof. Austin Burt. Concurrently, I completed an MA in English Literature at King’s College London, UK, writing on the representation of malaria in literature. Following a year of teaching natural sciences at a secondary school in Luxembourg and concluding a research internship at the Beijing Genomics Institute (BGI) in Shenzhen, China, I joined the Sanger PhD Programme in 2014.

Since joining the Sanger Institute, I have completed rotation projects with Dr. Julian Rayner and Dr. Oliver Billker, analysing vector integration efficiencies of PlasmoGEM vectors, with Dr. Matt Berriman, performing network analyses of dual RNA-seq data in rodent malaria, and with Prof. Dominic Kwiatkowski, developing selective Whole Genome Amplification (sWGA) protocols for human malaria samples. In 2015, I began my PhD project co-supervised by Dr. Matt Berriman and Prof. Dominic Kwiatkowski, as well as advised by Dr. Thomas Otto and Dr. Roberto Amato, analysing the genome sequences of neglected human malaria parasites and studying the genetic basis of antimalarial drug resistance.

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